Assay Detail
Binding
CHEMBL641206
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Affinity for Adenosine A1 receptor using [125I]APNEA in calf brain.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.27 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266161 | — | — | 1 | 8.50 |
| CHEMBL603400 | — | — | 1 | 8.38 |
| CHEMBL9335 | — | — | 1 | 8.21 |
| CHEMBL9725 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266161 | — | Ki | = | 3.17 | nM | 8.50 |
| CHEMBL603400 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL9335 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL9725 | — | Ki | = | 10.1 | nM | 8.00 |