Assay Detail
Binding
CHEMBL641222
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Acyl coenzyme A:cholesterol acyltransferase inhibition in cell culture measured in murine IC-21 macrophages.
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Intermediate |
Publication
Design, synthesis, and structure--activity relationship studies for a new imidazole series of J774 macrophage specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.17 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273826 | — | — | 1 | 8.52 |
| CHEMBL11232 | — | — | 1 | 8.40 |
| CHEMBL11201 | — | — | 1 | 7.80 |
| CHEMBL11612 | — | — | 1 | 7.54 |
| CHEMBL11071 | — | — | 1 | 7.50 |
| CHEMBL11248 | — | — | 1 | 7.40 |
| CHEMBL275479 | — | — | 1 | 7.30 |
| CHEMBL11303 | — | — | 1 | 7.22 |
| CHEMBL11091 | — | — | 1 | 7.10 |
| CHEMBL10307 | — | — | 1 | 7.10 |
| CHEMBL275265 | — | — | 1 | 6.60 |
| CHEMBL11379 | — | — | 1 | 6.54 |
| CHEMBL273510 | — | — | 1 | 6.47 |
| CHEMBL11316 | — | — | 1 | 6.44 |
| CHEMBL273824 | — | — | 1 | 6.44 |
| CHEMBL10916 | — | — | 1 | 6.35 |
| CHEMBL273825 | — | — | 1 | 6.30 |
| CHEMBL268700 | — | — | 1 | 6.24 |
| CHEMBL11526 | — | — | 1 | 6.20 |
| CHEMBL10954 | — | — | 1 | 6.19 |
| CHEMBL11254 | — | — | 1 | 6.19 |
| CHEMBL269469 | — | — | 1 | 6.08 |
| CHEMBL275308 | — | — | 1 | 6.08 |
| CHEMBL11267 | — | — | 1 | 6.08 |
| CHEMBL418529 | — | — | 1 | 6.06 |
| CHEMBL273532 | — | — | 1 | 6.03 |
| CHEMBL269386 | — | — | 1 | 6.00 |
| CHEMBL274185 | LECIMIBIDE | 2.0 | 1 | 6.00 |
| CHEMBL268024 | — | — | 1 | 6.00 |
| CHEMBL269470 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL11232 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL11201 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL11612 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL11071 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL11248 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL275479 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL11303 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL11091 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL10307 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL275265 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL11379 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL273510 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL273824 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL11316 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL10916 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL273825 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL268700 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL11526 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL10954 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL11254 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL269469 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL275308 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL11267 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL418529 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL273532 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL274185 | LECIMIBIDE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL268024 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL269386 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL269470 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL11197 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL273369 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL268478 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL274214 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL11072 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL268699 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL11204 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL439720 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL416705 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL274166 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL11400 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL275332 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL11445 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL11422 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL10844 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL11192 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL11110 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL11130 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL11631 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL11238 | — | IC50 | = | 7510.0 | nM | 5.12 |