Assay Detail
Binding
CHEMBL641336
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Inhibition of [125I]I-AB-MECA binding to human Adenosine A3 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.61 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68278 | — | — | 1 | 8.34 |
| CHEMBL302344 | — | — | 1 | 6.19 |
| CHEMBL39986 | — | — | 1 | 5.62 |
| CHEMBL67415 | — | — | 1 | 5.51 |
| CHEMBL63944 | — | — | 1 | 5.35 |
| CHEMBL67228 | — | — | 1 | 5.16 |
| CHEMBL67949 | — | — | 1 | 5.12 |
| CHEMBL67313 | — | — | 1 | 5.06 |
| CHEMBL304455 | — | — | 1 | 4.96 |
| CHEMBL66899 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68278 | — | Ki | = | 4.61 | nM | 8.34 |
| CHEMBL302344 | — | Ki | = | 639.0 | nM | 6.19 |
| CHEMBL39986 | — | Ki | = | 2370.0 | nM | 5.62 |
| CHEMBL67415 | — | Ki | = | 3080.0 | nM | 5.51 |
| CHEMBL63944 | — | Ki | = | 4440.0 | nM | 5.35 |
| CHEMBL67228 | — | Ki | = | 6880.0 | nM | 5.16 |
| CHEMBL67949 | — | Ki | = | 7510.0 | nM | 5.12 |
| CHEMBL67313 | — | Ki | = | 8650.0 | nM | 5.06 |
| CHEMBL304455 | — | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL66899 | — | Ki | = | 16100.0 | nM | 4.79 |