Assay Detail
Binding
CHEMBL641337
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Binding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor in the presence of GTPgammaS using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.16 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88147 | — | — | 1 | 8.92 |
| CHEMBL307199 | — | — | 1 | 8.41 |
| CHEMBL342873 | — | — | 1 | 8.40 |
| CHEMBL344187 | — | — | 1 | 7.62 |
| CHEMBL284969 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88147 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL307199 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL342873 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL344187 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL284969 | — | Ki | = | 34.0 | nM | 7.47 |