Assay Detail
Binding
CHEMBL641358
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In vitro inhibitory activity against aldose reductase isolated from human placenta
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 6.55 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 8.51 |
| CHEMBL143234 | — | — | 1 | 8.49 |
| CHEMBL422647 | — | — | 1 | 8.19 |
| CHEMBL341864 | — | — | 1 | 8.19 |
| CHEMBL143633 | — | — | 1 | 7.89 |
| CHEMBL344057 | — | — | 1 | 7.72 |
| CHEMBL143098 | — | — | 1 | 7.72 |
| CHEMBL139666 | — | — | 1 | 7.66 |
| CHEMBL345068 | — | — | 1 | 7.64 |
| CHEMBL358792 | — | — | 1 | 7.57 |
| CHEMBL2111988 | — | — | 1 | 7.55 |
| CHEMBL142599 | — | — | 1 | 7.55 |
| CHEMBL142989 | — | — | 1 | 7.51 |
| CHEMBL142790 | — | — | 1 | 7.50 |
| CHEMBL140199 | — | — | 1 | 7.47 |
| CHEMBL344526 | — | — | 1 | 7.43 |
| CHEMBL140012 | — | — | 1 | 7.30 |
| CHEMBL140750 | — | — | 1 | 7.28 |
| CHEMBL143211 | — | — | 1 | 7.11 |
| CHEMBL142274 | — | — | 1 | 7.05 |
| CHEMBL142879 | — | — | 1 | 6.96 |
| CHEMBL342339 | — | — | 1 | 6.92 |
| CHEMBL357460 | — | — | 1 | 6.82 |
| CHEMBL143551 | — | — | 1 | 6.82 |
| CHEMBL357206 | — | — | 1 | 6.81 |
| CHEMBL143231 | — | — | 1 | 6.80 |
| CHEMBL143863 | — | — | 1 | 6.77 |
| CHEMBL141013 | — | — | 1 | 6.70 |
| CHEMBL342974 | — | — | 1 | 6.70 |
| CHEMBL141390 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL143234 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL341864 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL422647 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL143633 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL344057 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL143098 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL139666 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL345068 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL358792 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2111988 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL142599 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL142989 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL142790 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL140199 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL344526 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL140012 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL140750 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL143211 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL142274 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL142879 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL342339 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL357460 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL143551 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL357206 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL143231 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL143863 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL141013 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL342974 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL141390 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL143241 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL141135 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL143872 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL357074 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL342524 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL143387 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL356545 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2111987 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL143903 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL356286 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL140042 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL357435 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL143569 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL342786 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL422824 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL342887 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL356789 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL424485 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL142542 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL143708 | — | IC50 | = | 2200.0 | nM | 5.66 |