Assay Detail
Binding
CHEMBL641360
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In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.37 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 6.40 |
| CHEMBL414496 | — | — | 1 | 5.50 |
| CHEMBL150198 | — | — | 1 | 5.50 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.44 |
| CHEMBL148864 | — | — | 1 | 5.36 |
| CHEMBL357100 | — | — | 1 | 5.26 |
| CHEMBL151952 | — | — | 1 | 5.24 |
| CHEMBL148918 | — | — | 1 | 5.05 |
| CHEMBL358713 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL414496 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL150198 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL266497 | SORBINIL | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL148864 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL357100 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL151952 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL148918 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL358713 | — | IC50 | = | 25000.0 | nM | 4.60 |