Assay Detail
Binding
CHEMBL641374
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Competitive Inhibitory activity against Golgi Alpha-mannosidase II
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.38 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL80254 | — | — | 1 | 4.46 |
| CHEMBL80148 | — | — | 1 | 4.29 |
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | - |
| CHEMBL310229 | — | — | 1 | - |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | - |
| CHEMBL75971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL80254 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL80148 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL307429 | DUVOGLUSTAT | Ki | < | 50000.0 | nM | - |
| CHEMBL310229 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL1029 | MIGLUSTAT | Ki | < | 50000.0 | nM | - |
| CHEMBL75971 | — | Ki | < | 50000.0 | nM | - |