Assay Detail
Binding
CHEMBL641384
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Tested for its inhibitory activity against alpha-2 adrenoceptor in guinea pig ileum
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.20 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77921 | MEDETOMIDINE | 3.0 | 1 | 8.52 |
| CHEMBL306751 | — | — | 3 | 8.05 |
| CHEMBL544765 | — | — | 1 | 7.75 |
| CHEMBL542155 | — | — | 1 | 6.43 |
| CHEMBL553835 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77921 | MEDETOMIDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL306751 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL306751 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL544765 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL542155 | — | EC50 | = | 375.0 | nM | 6.43 |
| CHEMBL553835 | — | EC50 | = | 32992.0 | nM | 4.48 |
| CHEMBL306751 | — | EC50 | = | - | nM | - |