Assay Detail
Functional
CHEMBL641400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human Alpha-1D adrenergic receptors expressed in rat-1 fibroblasts
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 7.30 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117248 | — | — | 1 | 8.10 |
| CHEMBL118055 | — | — | 1 | 7.70 |
| CHEMBL114669 | — | — | 1 | 7.50 |
| CHEMBL325745 | — | — | 1 | 7.10 |
| CHEMBL327005 | — | — | 1 | 7.00 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 6.90 |
| CHEMBL318544 | — | — | 1 | 6.80 |
| CHEMBL117581 | — | — | 1 | - |
| CHEMBL116843 | — | — | 1 | - |
| CHEMBL115977 | — | — | 1 | - |
| CHEMBL116700 | — | — | 1 | - |
| CHEMBL117094 | — | — | 1 | - |
| CHEMBL117482 | — | — | 1 | - |
| CHEMBL117914 | — | — | 1 | - |
| CHEMBL326837 | — | — | 1 | - |
| CHEMBL13789 | — | — | 1 | - |
| CHEMBL420683 | — | — | 1 | - |
| CHEMBL326067 | — | — | 1 | - |
| CHEMBL117381 | — | — | 1 | - |
| CHEMBL71001 | — | — | 1 | - |
| CHEMBL421011 | — | — | 1 | - |
| CHEMBL325648 | — | — | 1 | - |
| CHEMBL114054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117248 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL118055 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL114669 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL325745 | — | EC50 | = | 79.43 | nM | 7.10 |
| CHEMBL327005 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL318544 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL117581 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL116843 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL115977 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL116700 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL117094 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL117482 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL117914 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL326837 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL13789 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL420683 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL326067 | — | EC50 | < | 251.19 | nM | - |
| CHEMBL117381 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL71001 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL421011 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL325648 | — | EC50 | < | 5011.87 | nM | - |
| CHEMBL114054 | — | EC50 | < | 5011.87 | nM | - |