Assay Detail
Binding
CHEMBL641519
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Binding affinity for adenosine A3 receptor as inhibition of [125I]AB-MECA binding to human receptor expressed in HEK 293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.88 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.96 |
| CHEMBL296135 | — | — | 1 | 8.11 |
| CHEMBL50982 | — | — | 1 | 7.70 |
| CHEMBL301169 | — | — | 1 | 7.58 |
| CHEMBL49513 | — | — | 1 | 7.51 |
| CHEMBL49843 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL296135 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL50982 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL301169 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL49513 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL49843 | — | Ki | = | 41.0 | nM | 7.39 |