Assay Detail
Binding
CHEMBL641703
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In vitro inhibition of acyl coenzyme A:cholesterol acyltransferase 1, rat liver microsomal assay
35
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsomal |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted (1,2-diarylethyl)amide acyl-CoA:cholesterol acyltransferase inhibitors: effect of polar groups on in vitro and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.83 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41240 | — | — | 1 | 6.82 |
| CHEMBL40998 | — | — | 1 | 6.52 |
| CHEMBL289558 | — | — | 1 | 6.46 |
| CHEMBL42748 | — | — | 1 | 6.44 |
| CHEMBL41186 | — | — | 1 | 6.44 |
| CHEMBL40318 | — | — | 1 | 6.34 |
| CHEMBL41350 | — | — | 1 | 6.30 |
| CHEMBL441971 | — | — | 1 | 6.10 |
| CHEMBL41233 | — | — | 3 | 6.05 |
| CHEMBL296077 | — | — | 1 | 6.00 |
| CHEMBL418627 | — | — | 1 | 5.82 |
| CHEMBL42979 | — | — | 1 | 5.82 |
| CHEMBL41351 | — | — | 1 | 5.80 |
| CHEMBL39075 | — | — | 1 | 5.75 |
| CHEMBL42230 | — | — | 1 | 5.75 |
| CHEMBL38881 | — | — | 1 | 5.64 |
| CHEMBL289997 | — | — | 1 | 5.62 |
| CHEMBL42303 | — | — | 1 | 5.55 |
| CHEMBL277986 | CL-277082 | — | 1 | 5.50 |
| CHEMBL44043 | — | — | 1 | 5.46 |
| CHEMBL289124 | — | — | 1 | 5.40 |
| CHEMBL296920 | — | — | 1 | 5.30 |
| CHEMBL41208 | — | — | 1 | 5.30 |
| CHEMBL44349 | — | — | 1 | 5.30 |
| CHEMBL22373 | CL-976 | — | 1 | 5.22 |
| CHEMBL441970 | — | — | 1 | 5.00 |
| CHEMBL295584 | — | — | 1 | - |
| CHEMBL43805 | — | — | 1 | - |
| CHEMBL40354 | — | — | 1 | - |
| CHEMBL446610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41240 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL40998 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL289558 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL42748 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL41186 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL40318 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL41350 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL441971 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL41233 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL296077 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL41233 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL418627 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL42979 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL41351 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL39075 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL42230 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL41233 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL38881 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL289997 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL42303 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL277986 | CL-277082 | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL44043 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL289124 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL296920 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL44349 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL41208 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL22373 | CL-976 | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL441970 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL43805 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL295584 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL446610 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL42634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL44233 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL42197 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL40354 | — | IC50 | > | 10000.0 | nM | - |