Assay Detail
Binding
CHEMBL641706
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In vitro inhibition of Acyl coenzyme A:cholesterol acyltransferase 1 from rat liver.
17
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.92 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284029 | — | — | 1 | 8.40 |
| CHEMBL33842 | — | — | 1 | 7.82 |
| CHEMBL33780 | — | — | 1 | 7.60 |
| CHEMBL30860 | — | — | 2 | 7.26 |
| CHEMBL286812 | — | — | 1 | 7.12 |
| CHEMBL33661 | — | — | 1 | 7.07 |
| CHEMBL289465 | — | — | 2 | 7.05 |
| CHEMBL33271 | — | — | 1 | 7.00 |
| CHEMBL33288 | — | — | 1 | 6.96 |
| CHEMBL285659 | — | — | 1 | 6.75 |
| CHEMBL34173 | — | — | 1 | 6.58 |
| CHEMBL34221 | — | — | 1 | 6.56 |
| CHEMBL284153 | — | — | 1 | 6.54 |
| CHEMBL417493 | — | — | 1 | 6.04 |
| CHEMBL284952 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284029 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL33842 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL33780 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL30860 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL286812 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL33661 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL289465 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL33271 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL33288 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL289465 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL285659 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL30860 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL34173 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL34221 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL284153 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL417493 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL284952 | — | IC50 | = | 4800.0 | nM | 5.32 |