Assay Detail
Binding
CHEMBL641960
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Displacement of [3H]AB-MECA from human Adenosine A3 receptor expressed in HEK cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Selective A(3) adenosine receptor antagonists: water-soluble 3, 5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.21 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436180 | — | — | 1 | 6.66 |
| CHEMBL135569 | — | — | 1 | 6.46 |
| CHEMBL277079 | — | — | 1 | 6.44 |
| CHEMBL135361 | — | — | 1 | 6.42 |
| CHEMBL337088 | — | — | 1 | 6.36 |
| CHEMBL424079 | — | — | 1 | 6.33 |
| CHEMBL135356 | — | — | 1 | 6.32 |
| CHEMBL274501 | — | — | 1 | 6.27 |
| CHEMBL135323 | — | — | 1 | 6.24 |
| CHEMBL335740 | — | — | 1 | 6.16 |
| CHEMBL337503 | — | — | 1 | 5.90 |
| CHEMBL336629 | — | — | 1 | 5.87 |
| CHEMBL340552 | — | — | 1 | 5.85 |
| CHEMBL440720 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436180 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL135569 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL277079 | — | Ki | = | 364.0 | nM | 6.44 |
| CHEMBL135361 | — | Ki | = | 379.0 | nM | 6.42 |
| CHEMBL337088 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL424079 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL135356 | — | Ki | = | 483.0 | nM | 6.32 |
| CHEMBL274501 | — | Ki | = | 538.0 | nM | 6.27 |
| CHEMBL135323 | — | Ki | = | 577.0 | nM | 6.24 |
| CHEMBL335740 | — | Ki | = | 695.0 | nM | 6.16 |
| CHEMBL337503 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL336629 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL340552 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL440720 | — | Ki | = | 2020.0 | nM | 5.70 |