Assay Detail
Binding
CHEMBL642052
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In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens
8
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | - | - |
| Kd | 1 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542812 | — | — | 1 | 6.70 |
| CHEMBL553942 | — | — | 1 | - |
| CHEMBL554235 | — | — | 1 | - |
| CHEMBL554455 | — | — | 1 | - |
| CHEMBL30911 | — | — | 1 | - |
| CHEMBL3350238 | — | — | 2 | - |
| CHEMBL284056 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542812 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL553942 | — | IC50 | >> | 10000.0 | nM | - |
| CHEMBL554235 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL554455 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL30911 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3350238 | — | IC50 | >> | 1000.0 | nM | - |
| CHEMBL3350238 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL284056 | — | IC50 | >> | 1000.0 | nM | - |