Assay Detail
Binding
CHEMBL642060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for the concentration required to inhibit [3H]AMPA radioligand at AMPA receptor sites in rat cortical membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111651 | — | — | 1 | 7.52 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111651 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL276815 | (S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |