Assay Detail
Binding
CHEMBL642128
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Binding affinity determined by displacement of [3H]prazosin from alpha-1D adrenergic receptor
28
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.40 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 8.46 |
| CHEMBL91022 | — | — | 1 | 7.18 |
| CHEMBL327931 | — | — | 1 | 6.90 |
| CHEMBL279436 | — | — | 3 | 6.65 |
| CHEMBL91415 | — | — | 1 | 6.52 |
| CHEMBL315914 | — | — | 1 | 6.50 |
| CHEMBL313160 | — | — | 1 | 6.50 |
| CHEMBL327712 | — | — | 1 | 6.49 |
| CHEMBL284470 | — | — | 1 | 6.48 |
| CHEMBL313953 | — | — | 1 | 6.46 |
| CHEMBL89243 | — | — | 1 | 6.42 |
| CHEMBL327775 | — | — | 1 | 6.36 |
| CHEMBL314960 | — | — | 1 | 6.35 |
| CHEMBL88388 | — | — | 1 | 6.34 |
| CHEMBL91550 | — | — | 1 | 6.33 |
| CHEMBL315538 | — | — | 1 | 6.31 |
| CHEMBL88448 | — | — | 1 | 6.30 |
| CHEMBL89685 | — | — | 1 | 6.29 |
| CHEMBL5483012 | — | — | 1 | 6.27 |
| CHEMBL92322 | — | — | 1 | 6.13 |
| CHEMBL284103 | — | — | 1 | 6.12 |
| CHEMBL91956 | — | — | 1 | 5.94 |
| CHEMBL312871 | — | — | 1 | 5.94 |
| CHEMBL88628 | — | — | 1 | 5.82 |
| CHEMBL315392 | — | — | 1 | 5.77 |
| CHEMBL313251 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611 | TERAZOSIN | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL91022 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL327931 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL279436 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL91415 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL315914 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL313160 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL327712 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL284470 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL313953 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL89243 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL279436 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL327775 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL314960 | — | Ki | = | 446.68 | nM | 6.35 |
| CHEMBL88388 | — | Ki | = | 457.09 | nM | 6.34 |
| CHEMBL91550 | — | Ki | = | 467.74 | nM | 6.33 |
| CHEMBL315538 | — | Ki | = | 489.78 | nM | 6.31 |
| CHEMBL88448 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL89685 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL5483012 | — | Ki | = | 537.03 | nM | 6.27 |
| CHEMBL279436 | — | Ki | = | 602.56 | nM | 6.22 |
| CHEMBL92322 | — | Ki | = | 741.31 | nM | 6.13 |
| CHEMBL284103 | — | Ki | = | 758.58 | nM | 6.12 |
| CHEMBL91956 | — | Ki | = | 1148.15 | nM | 5.94 |
| CHEMBL312871 | — | Ki | = | 1148.15 | nM | 5.94 |
| CHEMBL88628 | — | Ki | = | 1513.56 | nM | 5.82 |
| CHEMBL315392 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL313251 | — | Ki | = | 1737.8 | nM | 5.76 |