Assay Detail
Binding
CHEMBL642253
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Binding affinity towards adenosine A1 receptor of bovine brain membrane in presence of [3H]CHA at a concentration of 20 uM
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.35 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280278 | — | — | 1 | 9.38 |
| CHEMBL16774 | — | — | 1 | 8.96 |
| CHEMBL276321 | — | — | 1 | 8.92 |
| CHEMBL274267 | — | — | 1 | 8.85 |
| CHEMBL275421 | — | — | 1 | 8.38 |
| CHEMBL16305 | — | — | 1 | 8.37 |
| CHEMBL16529 | — | — | 1 | 8.32 |
| CHEMBL279870 | — | — | 1 | 8.31 |
| CHEMBL280080 | — | — | 1 | 8.20 |
| CHEMBL416354 | — | — | 1 | 8.04 |
| CHEMBL274273 | — | — | 1 | 8.03 |
| CHEMBL278197 | — | — | 1 | 7.96 |
| CHEMBL16195 | — | — | 1 | 7.75 |
| CHEMBL273578 | — | — | 1 | 7.71 |
| CHEMBL416537 | — | — | 1 | 7.70 |
| CHEMBL16643 | — | — | 1 | 7.54 |
| CHEMBL16254 | — | — | 1 | 7.29 |
| CHEMBL16598 | — | — | 1 | 7.26 |
| CHEMBL16715 | — | — | 1 | 7.10 |
| CHEMBL16488 | — | — | 1 | 7.05 |
| CHEMBL279410 | — | — | 1 | 6.81 |
| CHEMBL16750 | — | — | 1 | 6.70 |
| CHEMBL16416 | — | — | 1 | 6.51 |
| CHEMBL16510 | — | — | 1 | 6.51 |
| CHEMBL277357 | — | — | 1 | 6.39 |
| CHEMBL16820 | — | — | 1 | 6.37 |
| CHEMBL280300 | — | — | 1 | 6.36 |
| CHEMBL16242 | — | — | 1 | 6.29 |
| CHEMBL274274 | — | — | 1 | 6.14 |
| CHEMBL16737 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280278 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL16774 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL276321 | — | Ki | = | 1.21 | nM | 8.92 |
| CHEMBL274267 | — | Ki | = | 1.43 | nM | 8.85 |
| CHEMBL275421 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL16305 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL16529 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL279870 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL280080 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL416354 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL274273 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL278197 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL16195 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL273578 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL416537 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL16643 | — | Ki | = | 28.5 | nM | 7.54 |
| CHEMBL16254 | — | Ki | = | 50.8 | nM | 7.29 |
| CHEMBL16598 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL16715 | — | Ki | = | 80.1 | nM | 7.10 |
| CHEMBL16488 | — | Ki | = | 89.6 | nM | 7.05 |
| CHEMBL279410 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL16750 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL16416 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL16510 | — | Ki | = | 309.0 | nM | 6.51 |
| CHEMBL277357 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL16820 | — | Ki | = | 426.0 | nM | 6.37 |
| CHEMBL280300 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL16242 | — | Ki | = | 515.0 | nM | 6.29 |
| CHEMBL274274 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL16737 | — | Ki | = | 934.0 | nM | 6.03 |
| CHEMBL276528 | — | Ki | = | 1015.0 | nM | 5.99 |
| CHEMBL16833 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL16215 | — | Ki | = | 2600.0 | nM | 5.58 |