Assay Detail
Binding
CHEMBL642254
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Binding affinity towards adenosine A1 receptor of bovine brain membrane using [3H]-CHA at 20 uM
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.33 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106265 | 8-CYCLOPENTYLTHEOPHYLLINE | — | 1 | 9.30 |
| CHEMBL16010 | — | — | 1 | 7.27 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106265 | 8-CYCLOPENTYLTHEOPHYLLINE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL16010 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 3800.0 | nM | 5.42 |