Assay Detail
Binding
CHEMBL642459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-aminoimidazole-4-carboxamide AICAR formyltransferase in MOLT-4 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | MOLT-4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bifunctional purine biosynthesis protein ATIC (CHEMBL2518) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.13 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157775 | — | — | 1 | 4.30 |
| CHEMBL157857 | — | — | 1 | 4.20 |
| CHEMBL13659 | — | — | 1 | 4.03 |
| CHEMBL156308 | — | — | 1 | 4.00 |
| CHEMBL157230 | — | — | 1 | - |
| CHEMBL156551 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157775 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL157857 | — | IC50 | = | 62800.0 | nM | 4.20 |
| CHEMBL13659 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL156308 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL157230 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL156551 | — | IC50 | = | 141000.0 | nM | - |