Assay Detail
Binding
CHEMBL642726
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex) derivaties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.67 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352500 | — | — | 1 | 8.63 |
| CHEMBL292314 | — | — | 1 | 8.54 |
| CHEMBL134057 | — | — | 1 | 8.35 |
| CHEMBL368196 | — | — | 1 | 8.19 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.04 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.03 |
| CHEMBL431844 | — | — | 1 | 7.93 |
| CHEMBL369661 | — | — | 1 | 7.44 |
| CHEMBL62084 | — | — | 1 | 7.40 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 7.22 |
| CHEMBL172118 | — | — | 1 | 7.11 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 6.56 |
| CHEMBL355740 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352500 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL292314 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL134057 | — | IC50 | = | 4.43 | nM | 8.35 |
| CHEMBL368196 | — | IC50 | = | 6.52 | nM | 8.19 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL95 | TACRINE | IC50 | = | 9.33 | nM | 8.03 |
| CHEMBL431844 | — | IC50 | = | 11.67 | nM | 7.93 |
| CHEMBL369661 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL62084 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 59.83 | nM | 7.22 |
| CHEMBL172118 | — | IC50 | = | 77.7 | nM | 7.11 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL355740 | — | IC50 | = | 493.3 | nM | 6.31 |