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Assay Detail

CHEMBL642755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration against A2AR mediated P12 adenylatencyclase activity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
Thompson RD, Secunda S, Daly JW, Olsson RA.
J Med Chem (1991) 34 : 3388 -3390
PubMed 1766003 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.85 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL315056 1 6.50
CHEMBL284969 1 6.14
CHEMBL139000 (R)-PIA 1 6.01
CHEMBL610407 1 5.80
CHEMBL312917 1 5.52
CHEMBL262083 N6-PHENYLADENOSINE 1 5.51
CHEMBL68738 N6-CYCLOPENTYLADENOSINE 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL315056 IC50 = 320.0 nM 6.50
CHEMBL284969 IC50 = 730.0 nM 6.14
CHEMBL139000 (R)-PIA IC50 = 980.0 nM 6.01
CHEMBL610407 IC50 = 1600.0 nM 5.80
CHEMBL312917 IC50 = 3000.0 nM 5.52
CHEMBL262083 N6-PHENYLADENOSINE IC50 = 3100.0 nM 5.51
CHEMBL68738 N6-CYCLOPENTYLADENOSINE IC50 = 3200.0 nM 5.50