Assay Detail
Binding
CHEMBL642823
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Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.15 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116123 | — | — | 1 | 10.40 |
| CHEMBL114362 | — | — | 1 | 9.51 |
| CHEMBL326724 | — | — | 1 | 9.49 |
| CHEMBL116055 | — | — | 1 | 9.31 |
| CHEMBL432980 | — | — | 1 | 9.24 |
| CHEMBL114685 | — | — | 1 | 8.96 |
| CHEMBL283795 | — | — | 1 | 8.74 |
| CHEMBL323924 | — | — | 1 | 8.43 |
| CHEMBL115130 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116123 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL114362 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL326724 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL116055 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL432980 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL114685 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL283795 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL323924 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL115130 | — | IC50 | = | 5.8 | nM | 8.24 |