Assay Detail
Binding
CHEMBL642845
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Inhibitory activity against acyl-CoA:cholesterol O-acyltransferase (ACAT)
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Chemical modification and structure-activity relationships of pyripyropenes; potent, bioavailable inhibitor of acyl-CoA: Cholesterol O-acyltransferase (ACAT)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.17 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330686 | — | — | 1 | 8.22 |
| CHEMBL91931 | — | — | 1 | 7.89 |
| CHEMBL327774 | — | — | 1 | 7.72 |
| CHEMBL90822 | — | — | 1 | 7.60 |
| CHEMBL88379 | — | — | 1 | 7.48 |
| CHEMBL89227 | — | — | 1 | 7.42 |
| CHEMBL328676 | — | — | 1 | 7.41 |
| CHEMBL89348 | — | — | 1 | 7.17 |
| CHEMBL310661 | — | — | 1 | 7.07 |
| CHEMBL88907 | — | — | 1 | 7.07 |
| CHEMBL25532 | — | — | 1 | 7.05 |
| CHEMBL329588 | — | — | 1 | 6.92 |
| CHEMBL422065 | — | — | 1 | 6.89 |
| CHEMBL421887 | — | — | 1 | 6.89 |
| CHEMBL89197 | — | — | 1 | 6.85 |
| CHEMBL91822 | — | — | 1 | 6.70 |
| CHEMBL91466 | — | — | 1 | 6.57 |
| CHEMBL314631 | — | — | 1 | 6.21 |
| CHEMBL432037 | — | — | 1 | 6.04 |
| CHEMBL327483 | — | — | 1 | 5.92 |
| CHEMBL91530 | — | — | 1 | 5.75 |
| CHEMBL90228 | — | — | 1 | 5.68 |
| CHEMBL441168 | — | — | 1 | 5.68 |
| CHEMBL328021 | — | — | 1 | 5.62 |
| CHEMBL315952 | — | — | 1 | 5.60 |
| CHEMBL91725 | — | — | 1 | 5.51 |
| CHEMBL330051 | — | — | 1 | 5.38 |
| CHEMBL91606 | — | — | 1 | 5.29 |
| CHEMBL89160 | — | — | 1 | 5.24 |
| CHEMBL88457 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330686 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL91931 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL327774 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL90822 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL88379 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL89227 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL328676 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL89348 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL310661 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL88907 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL25532 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL329588 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL422065 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL421887 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL89197 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL91822 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL91466 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL314631 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL432037 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL327483 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL91530 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL90228 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL441168 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL328021 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL315952 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL91725 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL330051 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL91606 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL89160 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL88457 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL328559 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL315860 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL311537 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL330039 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL329587 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL328544 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL91306 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL431209 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL329767 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL329584 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL88875 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL368221 | — | IC50 | > | 220000.0 | nM | - |