Assay Detail
Binding
CHEMBL642846
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Inhibitory activity was evaluated in rat liver microsomes using Acyl coenzyme A:cholesterol acyltransferase microsomal assay.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-oleoyl-1,2,3,4-tetrahydroisoquinolines as conformationally restricted inhibitors of acyl-CoA:cholesterol acyl transferase (ACAT)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.78 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41240 | — | — | 1 | 6.82 |
| CHEMBL154341 | — | — | 1 | 5.57 |
| CHEMBL154377 | — | — | 1 | 5.42 |
| CHEMBL152502 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41240 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL154341 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL154377 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL152502 | — | IC50 | = | 4800.0 | nM | 5.32 |