Assay Detail
Functional
CHEMBL642906
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Evaluated for norepinephrine as agonist.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Arylethanolamines derived from salicylamide with alpha- and beta-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers, and related salicylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.94 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.43 |
| CHEMBL1200323 | LABETALOL HYDROCHLORIDE | 4.0 | 1 | 7.44 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Kd | = | 3.715 | nM | 8.43 |
| CHEMBL1200323 | LABETALOL HYDROCHLORIDE | Kd | = | 36.31 | nM | 7.44 |
| CHEMBL27 | PROPRANOLOL | Kd | > | 100000.0 | nM | - |