Assay Detail
Binding
CHEMBL642909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration that produces 50 % displacement of specific [3H]clonidine binding to Alpha adrenergic receptor in rat brain cortical membrane preparations.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.21 |
| CHEMBL1788237 | — | — | 1 | 6.22 |
| CHEMBL119555 | — | — | 1 | 5.86 |
| CHEMBL2092951 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59 | DOPAMINE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1788237 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL119555 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL2092951 | — | IC50 | = | 27700.0 | nM | 4.56 |