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Assay Detail

CHEMBL642920

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]WB-4101 binding to alpha adrenergic receptor from rat cerebral cortical membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Subcellular Membrane
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha (CHEMBL2094111)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.
Brossi A, Rice KC, Mak CP, Reden J, Jacobson AE, Nimitkitpaisan Y, Skolnick P, Daly J.
J Med Chem (1980) 23 : 648 -652
PubMed 6248642 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.14 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL157948 1 6.30
CHEMBL347351 1 5.35
CHEMBL348881 1 5.30
CHEMBL349584 1 5.30
CHEMBL155870 1 5.12
CHEMBL155707 1 5.12
CHEMBL160579 1 5.00
CHEMBL174984 TRETOQUINOL 2.0 1 5.00
CHEMBL160919 TETRAHYDROPAPAVERINE 1 5.00
CHEMBL156383 1 4.60
CHEMBL19068 1 4.40
CHEMBL160143 1 -
CHEMBL160310 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL157948 Ki = 500.0 nM 6.30
CHEMBL347351 Ki = 4500.0 nM 5.35
CHEMBL348881 Ki = 5000.0 nM 5.30
CHEMBL349584 Ki = 5000.0 nM 5.30
CHEMBL155870 Ki = 7500.0 nM 5.12
CHEMBL155707 Ki = 7500.0 nM 5.12
CHEMBL160579 Ki = 10000.0 nM 5.00
CHEMBL174984 TRETOQUINOL Ki = 10000.0 nM 5.00
CHEMBL160919 TETRAHYDROPAPAVERINE Ki = 10000.0 nM 5.00
CHEMBL156383 Ki = 25000.0 nM 4.60
CHEMBL19068 Ki = 40000.0 nM 4.40
CHEMBL160143 Ki > 100000.0 nM -
CHEMBL160310 Ki > 100000.0 nM -