Assay Detail
Binding
CHEMBL642937
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Inhibition of aggrecanase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.43 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24398 | — | — | 1 | 7.92 |
| CHEMBL114804 | — | — | 1 | 7.79 |
| CHEMBL8943 | — | — | 1 | 7.19 |
| CHEMBL420487 | — | — | 1 | 6.74 |
| CHEMBL419751 | — | — | 1 | 6.48 |
| CHEMBL45483 | — | — | 1 | 6.43 |
| CHEMBL115082 | — | — | 1 | 6.10 |
| CHEMBL323874 | — | — | 1 | 5.88 |
| CHEMBL325048 | — | — | 1 | 5.77 |
| CHEMBL114357 | — | — | 1 | 5.50 |
| CHEMBL115712 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24398 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL114804 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL8943 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL420487 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL419751 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL45483 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL115082 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL323874 | — | IC50 | = | 1309.0 | nM | 5.88 |
| CHEMBL325048 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL114357 | — | IC50 | = | 3139.0 | nM | 5.50 |
| CHEMBL115712 | — | IC50 | = | 13333.0 | nM | 4.88 |