Assay Detail
Binding
CHEMBL642983
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Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.90 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42472 | — | — | 1 | 10.05 |
| CHEMBL44403 | — | — | 1 | 9.74 |
| CHEMBL43905 | — | — | 1 | 9.36 |
| CHEMBL25554 | — | — | 1 | 9.29 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.89 |
| CHEMBL42558 | — | — | 1 | 8.44 |
| CHEMBL42231 | — | — | 1 | 7.77 |
| CHEMBL40325 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42472 | — | Ki | = | 0.08913 | nM | 10.05 |
| CHEMBL44403 | — | Ki | = | 0.182 | nM | 9.74 |
| CHEMBL43905 | — | Ki | = | 0.4365 | nM | 9.36 |
| CHEMBL25554 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL42558 | — | Ki | = | 3.631 | nM | 8.44 |
| CHEMBL42231 | — | Ki | = | 16.98 | nM | 7.77 |
| CHEMBL40325 | — | Ki | = | 22.91 | nM | 7.64 |