Assay Detail
Binding
CHEMBL642984
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Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.40 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70751 | — | — | 1 | 8.33 |
| CHEMBL306792 | — | — | 1 | 8.30 |
| CHEMBL72768 | — | — | 1 | 8.21 |
| CHEMBL540542 | — | — | 1 | 7.95 |
| CHEMBL72441 | — | — | 1 | 7.76 |
| CHEMBL540035 | — | — | 1 | 7.24 |
| CHEMBL70691 | — | — | 1 | 6.97 |
| CHEMBL553276 | — | — | 1 | 6.65 |
| CHEMBL70692 | — | — | 1 | 6.52 |
| CHEMBL72724 | — | — | 1 | 6.32 |
| CHEMBL70563 | — | — | 1 | 6.06 |
| CHEMBL74114 | — | — | 1 | 6.04 |
| CHEMBL542402 | — | — | 1 | 5.92 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 5.87 |
| CHEMBL554416 | — | — | 1 | 5.86 |
| CHEMBL70326 | — | — | 1 | 5.79 |
| CHEMBL70973 | — | — | 1 | 5.65 |
| CHEMBL70634 | — | — | 1 | 5.62 |
| CHEMBL74467 | — | — | 1 | 5.58 |
| CHEMBL74071 | — | — | 1 | 5.55 |
| CHEMBL419448 | — | — | 1 | 5.46 |
| CHEMBL544290 | — | — | 1 | 5.42 |
| CHEMBL71479 | — | — | 1 | 5.32 |
| CHEMBL71001 | — | — | 1 | 5.12 |
| CHEMBL302698 | — | — | 1 | - |
| CHEMBL70740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70751 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL306792 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL72768 | — | Ki | = | 6.166 | nM | 8.21 |
| CHEMBL540542 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL72441 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL540035 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL70691 | — | Ki | = | 107.15 | nM | 6.97 |
| CHEMBL553276 | — | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL70692 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL72724 | — | Ki | = | 478.63 | nM | 6.32 |
| CHEMBL70563 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL74114 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL542402 | — | Ki | = | 1202.26 | nM | 5.92 |
| CHEMBL762 | OXYMETAZOLINE | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL554416 | — | Ki | = | 1380.38 | nM | 5.86 |
| CHEMBL70326 | — | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL70973 | — | Ki | = | 2238.72 | nM | 5.65 |
| CHEMBL70634 | — | Ki | = | 2398.83 | nM | 5.62 |
| CHEMBL74467 | — | Ki | = | 2630.27 | nM | 5.58 |
| CHEMBL74071 | — | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL419448 | — | Ki | = | 3467.37 | nM | 5.46 |
| CHEMBL544290 | — | Ki | = | 3801.89 | nM | 5.42 |
| CHEMBL71479 | — | Ki | = | 4786.3 | nM | 5.32 |
| CHEMBL71001 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL302698 | — | Ki | < | 15848.93 | nM | - |
| CHEMBL70740 | — | Ki | < | 15848.93 | nM | - |