Assay Detail
Binding
CHEMBL643074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzyme
33
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 5.58 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120302 | — | — | 1 | 6.66 |
| CHEMBL118107 | — | — | 3 | 6.52 |
| CHEMBL122307 | — | — | 1 | 6.43 |
| CHEMBL120008 | — | — | 1 | 6.26 |
| CHEMBL120142 | — | — | 1 | 6.21 |
| CHEMBL332774 | — | — | 1 | 6.15 |
| CHEMBL332631 | — | — | 1 | 6.12 |
| CHEMBL119628 | — | — | 2 | 6.11 |
| CHEMBL119933 | — | — | 1 | 5.96 |
| CHEMBL120906 | — | — | 1 | 5.75 |
| CHEMBL324097 | — | — | 1 | 5.70 |
| CHEMBL118966 | — | — | 1 | 5.57 |
| CHEMBL263490 | — | — | 1 | 5.57 |
| CHEMBL118726 | — | — | 1 | 5.54 |
| CHEMBL121009 | — | — | 1 | 5.54 |
| CHEMBL123646 | — | — | 1 | 5.50 |
| CHEMBL330778 | — | — | 1 | 5.46 |
| CHEMBL118407 | — | — | 1 | 5.41 |
| CHEMBL116762 | — | — | 1 | 5.30 |
| CHEMBL119643 | — | — | 1 | 5.29 |
| CHEMBL116375 | — | — | 1 | 5.24 |
| CHEMBL119937 | — | — | 1 | 5.02 |
| CHEMBL120258 | — | — | 1 | 4.96 |
| CHEMBL331772 | — | — | 1 | 4.89 |
| CHEMBL325656 | — | — | 1 | 4.75 |
| CHEMBL121651 | — | — | 1 | 4.72 |
| CHEMBL118408 | — | — | 1 | 4.68 |
| CHEMBL120393 | — | — | 1 | 4.39 |
| CHEMBL120641 | — | — | 1 | 4.19 |
| CHEMBL120253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120302 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL118107 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL118107 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL122307 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL120008 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL118107 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL120142 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL332774 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL332631 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL119628 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL119628 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL119933 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL120906 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL324097 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL263490 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL118966 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL118726 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL121009 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL123646 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL330778 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL118407 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL116762 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL119643 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL116375 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL119937 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL120258 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL331772 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL325656 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL121651 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL118408 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL120393 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL120641 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL120253 | — | Ki | = | 160000.0 | nM | - |