Assay Detail
Binding
CHEMBL643096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against aldose reductase isolated from human placenta
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.39 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69956 | — | — | 1 | 8.68 |
| CHEMBL71966 | — | — | 1 | 8.48 |
| CHEMBL304995 | — | — | 1 | 8.40 |
| CHEMBL73505 | — | — | 1 | 8.34 |
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 1 | 8.32 |
| CHEMBL73560 | — | — | 1 | 8.30 |
| CHEMBL68580 | — | — | 1 | 8.28 |
| CHEMBL69350 | — | — | 1 | 7.80 |
| CHEMBL303210 | — | — | 1 | 7.75 |
| CHEMBL21091 | — | — | 1 | 7.72 |
| CHEMBL305064 | — | — | 1 | 7.58 |
| CHEMBL308216 | — | — | 1 | 7.52 |
| CHEMBL66006 | — | — | 1 | 7.50 |
| CHEMBL306244 | — | — | 1 | 7.48 |
| CHEMBL68705 | — | — | 1 | 7.46 |
| CHEMBL309132 | — | — | 1 | 7.39 |
| CHEMBL69537 | — | — | 1 | 7.34 |
| CHEMBL67591 | — | — | 1 | 7.24 |
| CHEMBL421487 | — | — | 1 | 7.19 |
| CHEMBL69907 | — | — | 1 | 7.00 |
| CHEMBL419254 | — | — | 1 | 6.96 |
| CHEMBL68586 | — | — | 1 | 6.54 |
| CHEMBL69183 | — | — | 1 | 6.47 |
| CHEMBL67922 | — | — | 1 | 6.38 |
| CHEMBL70247 | — | — | 1 | 6.17 |
| CHEMBL69371 | — | — | 1 | 6.12 |
| CHEMBL306222 | — | — | 1 | 5.21 |
| CHEMBL66920 | — | — | 1 | - |
| CHEMBL69591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69956 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL71966 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL304995 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL73505 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL73560 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68580 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL69350 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL303210 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL21091 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL305064 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL308216 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL66006 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL306244 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL68705 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL309132 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL69537 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL67591 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL421487 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL69907 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL419254 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL68586 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL69183 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL67922 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL70247 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL69371 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL306222 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL66920 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL69591 | — | IC50 | < | 10.0 | nM | - |