Assay Detail
Binding
CHEMBL643099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human placental aldose reductase.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.12 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266773 | — | — | 1 | 6.70 |
| CHEMBL7415 | — | — | 1 | 6.62 |
| CHEMBL269550 | — | — | 1 | 6.58 |
| CHEMBL7224 | — | — | 1 | 6.52 |
| CHEMBL7183 | — | — | 1 | 6.51 |
| CHEMBL6944 | — | — | 1 | 6.42 |
| CHEMBL414208 | — | — | 1 | 6.39 |
| CHEMBL6828 | — | — | 1 | 6.36 |
| CHEMBL7603 | — | — | 1 | 6.30 |
| CHEMBL269089 | — | — | 1 | 6.08 |
| CHEMBL267651 | — | — | 1 | 5.92 |
| CHEMBL7749 | — | — | 1 | 5.72 |
| CHEMBL7658 | — | — | 1 | 5.64 |
| CHEMBL266772 | — | — | 1 | 5.64 |
| CHEMBL7461 | — | — | 1 | 5.60 |
| CHEMBL7541 | — | — | 1 | 5.58 |
| CHEMBL7304 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266773 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7415 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL269550 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL7224 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL7183 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL6944 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL414208 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL6828 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL7603 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL269089 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL267651 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL7749 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL7658 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL266772 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL7461 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL7541 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL7304 | — | IC50 | = | 3300.0 | nM | 5.48 |