Assay Detail
Binding
CHEMBL643104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human placental aldose reductase in Orange A column at day 2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.11 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170853 | — | — | 1 | 5.50 |
| CHEMBL168614 | — | — | 1 | 4.72 |
| CHEMBL168453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170853 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL168614 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL168453 | — | IC50 | = | 280000.0 | nM | - |