Assay Detail
Binding
CHEMBL643105
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Inhibitory activity against human placental aldose reductase in Orange A column at day 8
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.04 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422920 | — | — | 1 | 5.51 |
| CHEMBL170853 | — | — | 1 | 5.40 |
| CHEMBL168614 | — | — | 1 | 5.14 |
| CHEMBL171315 | — | — | 1 | 5.05 |
| CHEMBL63055 | ALRESTATIN | 2.0 | 1 | 4.10 |
| CHEMBL168453 | — | — | 1 | - |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422920 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL170853 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL168614 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL171315 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL63055 | ALRESTATIN | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL168453 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL266497 | SORBINIL | IC50 | = | 1400000.0 | nM | - |