Assay Detail
Binding
CHEMBL643107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human placental aldose reductase in Sepharose 4B column at day 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.10 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170853 | — | — | 1 | 5.35 |
| CHEMBL422920 | — | — | 1 | 5.33 |
| CHEMBL168614 | — | — | 1 | 5.30 |
| CHEMBL168453 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170853 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL422920 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL168614 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL168453 | — | IC50 | = | 38000.0 | nM | 4.42 |