Assay Detail
Binding
CHEMBL643110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for in vitro inhibition activity against human Aldose reductase (human AR)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.88 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 8.05 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL266497 | SORBINIL | IC50 | = | 2000.0 | nM | 5.70 |