Assay Detail
Binding
CHEMBL643204
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Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL4559) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Benzothiazol-2-ylcarboxylic acids with diverse spacers: A novel class of potent, orally active aldose reductase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.91 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44717 | — | — | 1 | 8.18 |
| CHEMBL288748 | — | — | 1 | 8.15 |
| CHEMBL44780 | — | — | 1 | 8.08 |
| CHEMBL44743 | — | — | 1 | 8.08 |
| CHEMBL47614 | — | — | 1 | 8.06 |
| CHEMBL45074 | — | — | 1 | 8.06 |
| CHEMBL45751 | — | — | 1 | 8.03 |
| CHEMBL46074 | — | — | 1 | 8.03 |
| CHEMBL47646 | — | — | 1 | 8.02 |
| CHEMBL46170 | — | — | 1 | 8.02 |
| CHEMBL43995 | — | — | 1 | 8.01 |
| CHEMBL442690 | — | — | 1 | 7.96 |
| CHEMBL45290 | — | — | 1 | 7.96 |
| CHEMBL542104 | — | — | 1 | 7.92 |
| CHEMBL10413 | ZENARESTAT | 2.0 | 1 | 7.92 |
| CHEMBL296769 | — | — | 1 | 7.89 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.80 |
| CHEMBL297861 | — | — | 1 | 7.72 |
| CHEMBL45352 | — | — | 1 | 7.68 |
| CHEMBL44941 | — | — | 1 | 7.64 |
| CHEMBL296780 | — | — | 1 | 7.42 |
| CHEMBL431145 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44717 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL288748 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL44780 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL44743 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL47614 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL45074 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL45751 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL46074 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL47646 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL46170 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL43995 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL442690 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL45290 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL542104 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL10413 | ZENARESTAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL296769 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL297861 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL45352 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL44941 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL296780 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL431145 | — | IC50 | = | 50.0 | nM | 7.30 |