Assay Detail
Binding
CHEMBL643228
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Binding affinity for human Alpha-2A adrenergic receptor from cultured LM(tk-) cells using [3H]rauwolscine
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacological evaluation of UK-14,304 analogs at cloned human adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.69 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74283 | — | — | 1 | 8.19 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 8.17 |
| CHEMBL70676 | — | — | 1 | 8.17 |
| CHEMBL49137 | — | — | 1 | 8.14 |
| CHEMBL72753 | — | — | 1 | 7.43 |
| CHEMBL72147 | — | — | 1 | 7.13 |
| CHEMBL49395 | — | — | 1 | 6.51 |
| CHEMBL72995 | — | — | 1 | 5.42 |
| CHEMBL73392 | — | — | 1 | 4.99 |
| CHEMBL74342 | — | — | 1 | 4.83 |
| CHEMBL73164 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74283 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL844 | BRIMONIDINE | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL70676 | — | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL49137 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL72753 | — | Ki | = | 37.15 | nM | 7.43 |
| CHEMBL72147 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL49395 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL72995 | — | Ki | = | 3801.89 | nM | 5.42 |
| CHEMBL73392 | — | Ki | = | 10232.93 | nM | 4.99 |
| CHEMBL74342 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL73164 | — | Ki | = | 26302.68 | nM | 4.58 |