Assay Detail
Binding
CHEMBL643422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% inhibition of binding against human Alpha-1D adrenergic receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.78 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95523 | — | — | 1 | 7.05 |
| CHEMBL320419 | — | — | 1 | 5.83 |
| CHEMBL97044 | — | — | 1 | 5.77 |
| CHEMBL319553 | — | — | 1 | 5.70 |
| CHEMBL421011 | — | — | 1 | 5.18 |
| CHEMBL450018 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95523 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL320419 | — | IC50 | = | 1479.11 | nM | 5.83 |
| CHEMBL97044 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL319553 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL421011 | — | IC50 | = | 6606.93 | nM | 5.18 |
| CHEMBL450018 | — | IC50 | = | 6760.83 | nM | 5.17 |