Assay Detail
Functional
CHEMBL643542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 7.84 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72441 | — | — | 1 | 9.96 |
| CHEMBL70751 | — | — | 1 | 9.36 |
| CHEMBL70691 | — | — | 1 | 8.80 |
| CHEMBL71479 | — | — | 1 | 8.71 |
| CHEMBL72768 | — | — | 1 | 8.64 |
| CHEMBL70634 | — | — | 1 | 8.55 |
| CHEMBL540035 | — | — | 1 | 8.47 |
| CHEMBL553276 | — | — | 1 | 8.30 |
| CHEMBL70692 | — | — | 1 | 8.11 |
| CHEMBL306792 | — | — | 1 | 8.11 |
| CHEMBL72724 | — | — | 1 | 7.98 |
| CHEMBL71001 | — | — | 1 | 7.85 |
| CHEMBL74467 | — | — | 1 | 7.78 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 7.69 |
| CHEMBL419448 | — | — | 1 | 7.62 |
| CHEMBL74114 | — | — | 1 | 7.38 |
| CHEMBL72958 | NS-49 | — | 1 | 6.80 |
| CHEMBL70973 | — | — | 1 | 6.62 |
| CHEMBL70563 | — | — | 1 | 6.29 |
| CHEMBL302698 | — | — | 1 | 5.96 |
| CHEMBL74071 | — | — | 1 | 5.71 |
| CHEMBL70740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72441 | — | EC50 | = | 0.1096 | nM | 9.96 |
| CHEMBL70751 | — | EC50 | = | 0.4365 | nM | 9.36 |
| CHEMBL70691 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL71479 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL72768 | — | EC50 | = | 2.291 | nM | 8.64 |
| CHEMBL70634 | — | EC50 | = | 2.818 | nM | 8.55 |
| CHEMBL540035 | — | EC50 | = | 3.388 | nM | 8.47 |
| CHEMBL553276 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL70692 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL306792 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL72724 | — | EC50 | = | 10.47 | nM | 7.98 |
| CHEMBL71001 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL74467 | — | EC50 | = | 16.6 | nM | 7.78 |
| CHEMBL762 | OXYMETAZOLINE | EC50 | = | 20.42 | nM | 7.69 |
| CHEMBL419448 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL74114 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL72958 | NS-49 | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL70973 | — | EC50 | = | 239.88 | nM | 6.62 |
| CHEMBL70563 | — | EC50 | = | 512.86 | nM | 6.29 |
| CHEMBL302698 | — | EC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL74071 | — | EC50 | = | 1949.84 | nM | 5.71 |
| CHEMBL70740 | — | EC50 | < | 100000.0 | nM | - |