Assay Detail
Binding
CHEMBL643555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition adenosine kinase activity in rat brain in vitro
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.79 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150370 | — | — | 1 | 9.60 |
| CHEMBL150478 | — | — | 1 | 9.37 |
| CHEMBL348712 | — | — | 1 | 9.26 |
| CHEMBL356896 | — | — | 1 | 9.01 |
| CHEMBL346622 | — | — | 1 | 8.52 |
| CHEMBL342310 | — | — | 1 | 8.51 |
| CHEMBL151448 | — | — | 1 | 8.49 |
| CHEMBL151812 | — | — | 1 | 8.40 |
| CHEMBL151214 | — | — | 1 | 8.30 |
| CHEMBL422489 | — | — | 1 | 8.30 |
| CHEMBL151079 | — | — | 1 | 8.17 |
| CHEMBL68492 | — | — | 1 | 8.15 |
| CHEMBL356256 | — | — | 1 | 7.80 |
| CHEMBL358714 | — | — | 1 | 7.43 |
| CHEMBL435646 | — | — | 1 | 7.26 |
| CHEMBL265251 | — | — | 1 | 7.22 |
| CHEMBL439635 | — | — | 1 | 7.20 |
| CHEMBL147390 | — | — | 1 | 6.52 |
| CHEMBL150978 | — | — | 1 | 6.46 |
| CHEMBL147356 | — | — | 1 | 6.40 |
| CHEMBL151553 | — | — | 1 | 6.39 |
| CHEMBL66338 | — | — | 1 | 6.36 |
| CHEMBL303499 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150370 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL150478 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL348712 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL356896 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL346622 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL342310 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL151448 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL151812 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL151214 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL422489 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL151079 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL68492 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL356256 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL358714 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL435646 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL265251 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL439635 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL147390 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL150978 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL147356 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL151553 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL66338 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL303499 | — | IC50 | = | 773.0 | nM | 6.11 |