Assay Detail
Binding
CHEMBL643556
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Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.86 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169457 | — | — | 1 | 9.77 |
| CHEMBL169385 | — | — | 1 | 9.64 |
| CHEMBL168574 | — | — | 1 | 9.60 |
| CHEMBL66089 | — | — | 1 | 8.70 |
| CHEMBL366974 | — | — | 1 | 8.70 |
| CHEMBL354271 | — | — | 1 | 8.52 |
| CHEMBL368195 | — | — | 1 | 8.52 |
| CHEMBL353017 | — | — | 1 | 8.30 |
| CHEMBL68749 | — | — | 1 | 8.30 |
| CHEMBL68492 | — | — | 1 | 8.15 |
| CHEMBL302921 | — | — | 1 | 8.10 |
| CHEMBL168703 | — | — | 1 | 8.05 |
| CHEMBL434500 | — | — | 1 | 8.05 |
| CHEMBL354370 | — | — | 1 | 8.00 |
| CHEMBL169916 | — | — | 1 | 7.96 |
| CHEMBL354881 | — | — | 1 | 7.89 |
| CHEMBL170969 | — | — | 1 | 7.82 |
| CHEMBL169165 | — | — | 1 | 7.77 |
| CHEMBL352742 | — | — | 1 | 7.77 |
| CHEMBL169340 | — | — | 1 | 7.68 |
| CHEMBL169700 | — | — | 1 | 7.52 |
| CHEMBL172339 | — | — | 1 | 7.46 |
| CHEMBL168214 | — | — | 1 | 7.44 |
| CHEMBL352710 | — | — | 1 | 7.42 |
| CHEMBL538655 | — | — | 1 | 7.36 |
| CHEMBL169250 | — | — | 1 | 7.33 |
| CHEMBL169917 | — | — | 1 | 7.26 |
| CHEMBL170905 | — | — | 1 | 7.21 |
| CHEMBL171006 | — | — | 1 | 7.11 |
| CHEMBL169512 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169457 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL169385 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL168574 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL66089 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL366974 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL354271 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL368195 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL353017 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68749 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68492 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL302921 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL168703 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL434500 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL354370 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL169916 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL354881 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL170969 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL169165 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL352742 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL169340 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL169700 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL172339 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL168214 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL352710 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL538655 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL169250 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL169917 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL170905 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL171006 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL169512 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL66338 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL171566 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL303499 | — | IC50 | = | 733.0 | nM | 6.13 |