Assay Detail
Functional
CHEMBL643579
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Agonist potency at Alpha-2A adrenergic receptor expressed in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.66 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70692 | — | — | 1 | 7.00 |
| CHEMBL540035 | — | — | 1 | 6.60 |
| CHEMBL553276 | — | — | 1 | 6.38 |
| CHEMBL70973 | — | — | 1 | - |
| CHEMBL419448 | — | — | 1 | - |
| CHEMBL74071 | — | — | 1 | - |
| CHEMBL542402 | — | — | 1 | - |
| CHEMBL70326 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70692 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL540035 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL553276 | — | EC50 | = | 416.87 | nM | 6.38 |
| CHEMBL70973 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL419448 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL74071 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL542402 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL70326 | — | EC50 | < | 10000.0 | nM | - |