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Assay Detail

CHEMBL643589

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity at Angiotensin II type 2 receptor.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Type-2 angiotensin II receptor (CHEMBL257)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD, Timmermans PB.
J Med Chem (1996) 39 : 625 -656
PubMed 8576904 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 7.67 9.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL100119 1 9.55
CHEMBL160494 1 9.54
CHEMBL73876 1 9.41
CHEMBL302102 1 9.15
CHEMBL302519 1 9.03
CHEMBL158795 1 8.70
CHEMBL74476 1 8.62
CHEMBL60942 1 8.52
CHEMBL292150 1 7.77
CHEMBL290286 1 7.52
CHEMBL157946 1 7.47
CHEMBL294558 1 7.16
CHEMBL291803 1 7.10
CHEMBL159004 1 6.89
CHEMBL71925 1 6.85
CHEMBL123562 1 6.62
CHEMBL42101 1 6.52
CHEMBL279629 L-159913 1 6.35
CHEMBL135089 1 6.31
CHEMBL59957 1 6.30
CHEMBL24861 1 5.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL100119 IC50 = 0.28 nM 9.55
CHEMBL160494 IC50 = 0.29 nM 9.54
CHEMBL73876 IC50 = 0.39 nM 9.41
CHEMBL302102 IC50 = 0.7 nM 9.15
CHEMBL302519 IC50 = 0.94 nM 9.03
CHEMBL158795 IC50 = 2.0 nM 8.70
CHEMBL74476 IC50 = 2.4 nM 8.62
CHEMBL60942 IC50 = 3.0 nM 8.52
CHEMBL292150 IC50 = 17.0 nM 7.77
CHEMBL290286 IC50 = 30.0 nM 7.52
CHEMBL157946 IC50 = 34.0 nM 7.47
CHEMBL294558 IC50 = 70.0 nM 7.16
CHEMBL291803 IC50 = 80.0 nM 7.10
CHEMBL159004 IC50 = 130.0 nM 6.89
CHEMBL71925 IC50 = 140.0 nM 6.85
CHEMBL123562 IC50 = 240.0 nM 6.62
CHEMBL42101 IC50 = 300.0 nM 6.52
CHEMBL279629 L-159913 IC50 = 450.0 nM 6.35
CHEMBL135089 IC50 = 490.0 nM 6.31
CHEMBL59957 IC50 = 500.0 nM 6.30
CHEMBL24861 IC50 = 2200.0 nM 5.66