Assay Detail
Binding
CHEMBL643591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 9.11 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98665 | — | — | 2 | 10.22 |
| CHEMBL430659 | — | — | 1 | 10.00 |
| CHEMBL98047 | — | — | 1 | 9.82 |
| CHEMBL317962 | — | — | 1 | 9.80 |
| CHEMBL433005 | — | — | 1 | 9.66 |
| CHEMBL100119 | — | — | 1 | 9.60 |
| CHEMBL316503 | — | — | 1 | 9.31 |
| CHEMBL60942 | — | — | 1 | 9.00 |
| CHEMBL99112 | — | — | 1 | 9.00 |
| CHEMBL328602 | — | — | 1 | 9.00 |
| CHEMBL98746 | — | — | 1 | 9.00 |
| CHEMBL317159 | — | — | 1 | 9.00 |
| CHEMBL294512 | — | — | 1 | 8.52 |
| CHEMBL415502 | — | — | 1 | 8.52 |
| CHEMBL99438 | — | — | 1 | 8.40 |
| CHEMBL101039 | — | — | 1 | 8.30 |
| CHEMBL304022 | — | — | 1 | 8.15 |
| CHEMBL101455 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98665 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL430659 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL98047 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL317962 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL98665 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL433005 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL100119 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL316503 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL317159 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL99112 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL328602 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL60942 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL98746 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL294512 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL415502 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL99438 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL101039 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL304022 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL101455 | — | IC50 | = | 10.0 | nM | 8.00 |