Assay Detail
Binding
CHEMBL643609
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Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.10 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | 4.0 | 1 | 8.47 |
| CHEMBL359031 | — | — | 1 | 8.20 |
| CHEMBL422130 | — | — | 1 | 7.96 |
| CHEMBL144318 | — | — | 1 | 7.72 |
| CHEMBL144901 | — | — | 1 | 7.64 |
| CHEMBL343034 | — | — | 1 | 7.62 |
| CHEMBL141667 | — | — | 1 | 7.57 |
| CHEMBL342730 | — | — | 1 | 7.47 |
| CHEMBL356799 | — | — | 1 | 7.27 |
| CHEMBL357019 | — | — | 1 | 7.17 |
| CHEMBL331545 | — | — | 1 | 7.16 |
| CHEMBL144767 | — | — | 1 | 7.15 |
| CHEMBL144710 | — | — | 1 | 7.05 |
| CHEMBL355917 | — | — | 1 | 6.72 |
| CHEMBL344335 | — | — | 1 | 6.72 |
| CHEMBL145712 | — | — | 1 | 6.55 |
| CHEMBL141721 | — | — | 1 | 6.30 |
| CHEMBL143617 | — | — | 1 | 6.00 |
| CHEMBL343444 | — | — | 1 | 5.64 |
| CHEMBL144362 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12713 | SERTINDOLE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL359031 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL422130 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL144318 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL144901 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL343034 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL141667 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL342730 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL356799 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL357019 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL331545 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL144767 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL144710 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL355917 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL344335 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL145712 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL141721 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL143617 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL343444 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL144362 | — | IC50 | = | 2700.0 | nM | 5.57 |