Assay Detail
Binding
CHEMBL643613
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Binding affinity for rat cortex alpha-1 adrenergic receptor by inhibition of [3H]prazosin binding
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.69 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127400 | — | — | 1 | 8.24 |
| CHEMBL420510 | — | — | 1 | 7.48 |
| CHEMBL124444 | — | — | 1 | 7.44 |
| CHEMBL25236 | BP-897 | — | 1 | 7.22 |
| CHEMBL339960 | — | — | 1 | 6.26 |
| CHEMBL340641 | — | — | 1 | 6.20 |
| CHEMBL125916 | — | — | 1 | 6.18 |
| CHEMBL435218 | — | — | 1 | 6.11 |
| CHEMBL126889 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127400 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL420510 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL124444 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL25236 | BP-897 | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL339960 | — | Ki | = | 547.0 | nM | 6.26 |
| CHEMBL340641 | — | Ki | = | 629.0 | nM | 6.20 |
| CHEMBL125916 | — | Ki | = | 666.0 | nM | 6.18 |
| CHEMBL435218 | — | Ki | = | 779.0 | nM | 6.11 |
| CHEMBL126889 | — | Ki | = | 8100.0 | nM | 5.09 |