Assay Detail
Binding
CHEMBL643614
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Binding affinity for Alpha-1 adrenergic receptor measured by displacing [3H]prazosin from rat cortical membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.02 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301707 | — | — | 1 | 9.68 |
| CHEMBL54716 | — | — | 1 | 9.49 |
| CHEMBL57163 | — | — | 1 | 9.28 |
| CHEMBL51963 | — | — | 1 | 8.74 |
| CHEMBL55528 | — | — | 1 | 7.89 |
| CHEMBL52473 | — | — | 1 | - |
| CHEMBL57398 | — | — | 1 | - |
| CHEMBL55338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301707 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL54716 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL57163 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL51963 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL55528 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL52473 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL57398 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL55338 | — | Ki | >= | 10000.0 | nM | - |