Assay Detail
Functional
CHEMBL643652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.33 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345076 | — | — | 1 | 8.85 |
| CHEMBL369744 | — | — | 1 | 8.80 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.55 |
| CHEMBL133387 | — | — | 1 | 8.48 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.44 |
| CHEMBL139417 | — | — | 1 | 8.27 |
| CHEMBL464859 | NECA | — | 1 | 7.58 |
| CHEMBL139000 | (R)-PIA | — | 1 | 7.57 |
| CHEMBL66393 | — | — | 1 | 7.07 |
| CHEMBL141792 | — | — | 1 | 6.80 |
| CHEMBL420705 | (S)-PIA | — | 1 | 6.68 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.62 |
| CHEMBL337602 | — | — | 1 | 6.09 |
| CHEMBL138746 | — | — | 1 | 6.08 |
| CHEMBL285819 | — | — | 1 | 5.79 |
| CHEMBL290077 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345076 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL369744 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL431733 | NAMODENOSON | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL133387 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL119709 | IB-MECA | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL139417 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL464859 | NECA | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL139000 | (R)-PIA | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL66393 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL141792 | — | EC50 | = | 158.0 | nM | 6.80 |
| CHEMBL420705 | (S)-PIA | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | EC50 | = | 242.0 | nM | 6.62 |
| CHEMBL337602 | — | EC50 | = | 803.0 | nM | 6.09 |
| CHEMBL138746 | — | EC50 | = | 828.0 | nM | 6.08 |
| CHEMBL285819 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL290077 | — | EC50 | = | 2660.0 | nM | 5.58 |